As a way station on Mito Highway, Niijuku was located between Senju-shuku and Matsudo-shuku. Since the daimyo of Sankinkōtai (daimyo's alternate-year residence in Edo) stayed in Senju-shuku or Matsudo-shuku, Niijuku was a small post station with no Honjin (officially appointed inns for daimyo) or Wakihonjin (inns appointed as supplementary for Honjin). There was a ferryboat landing point for crossing Nakagawa River there.